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KMID : 1123920040180051494
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 5 p.1494 ~ p.1504
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Study on Anti-thrombotic Activity, Superoxide Generation in Human Neutrophils and Platelet Aggregation in Human Blood of Hwao-tang
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Park Won-Hwan
Park Soo-Young
Park Tae-Woo
Kim Jong-Gu
Kim Seog-Ha
Kim Cherl-Ho
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Abstract
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The present paper reports the effects of Hwaotang an atherosclerosis using a spontaneous experimental model, We have also investigated the pharmacological effect of Hwaotang on collagen- and ADP-induced blood platelet aggregation, thrombin-induced conversion of fibrinogen and fibrinolysis in in vitro experiments, and various effects on stimuli-induced superoxide generation in human neutrophils. Hwao-tang was shown to have inhibitory effect on collagen- and ADP-induced blood platelet aggregation, on thrombin-induced conversion of fibrinogen to fibrin and on the activity of plasminogen or plasmin. Hwao-tang also significantly inhibited fMLP-induced superoxide generation in a concentration-dependent manner, but not that induced by arachidonic acid. Hwao-tang inhibited neutrophil functions, including degranulation, superoxide generation, and leukotriene B4 production, without any effect on 5-lipoxygenase activity. In conclusion, the protection of extracts of Hwao-tang on the ischemic infarction induced artificially might be involved to their inhibition of thrombotic action. The results also indicate that Hwao-tang exerts the effects on superoxide generation related to the inhibition of neutrophil functions.
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KEYWORD
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Hwao-tang(huayutang, 化瘀湯), thrombosis, activating blood circulation and eliminating blood stasis, aggregation, atherosclerosis, superoxide generation, neutrophils
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